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R Couture Selected Research

2- ((3- (1,3- benzodioxol- 5- yl)- 3- (((6- methoxy- 2- naphthyl)sulfonyl)amino)propanoyl)amino)- 3- (4- ((2,6- dimethylpiperidinyl)methyl)phenyl)- N- isopropyl- N- methylpropanamide

1/2017Impact of pioglitazone and bradykinin type 1 receptor antagonist on type 2 diabetes in high-fat diet-fed C57BL/6J mice.
4/2015A primary role for kinin B1 receptor in inflammation, organ damage, and lethal thrombosis in a rat model of septic shock in diabetes.
3/2012Blockade of kinin B(1) receptor reverses plasma fatty acids composition changes and body and tissue fat gain in a rat model of insulin resistance.
9/2007The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance.

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R Couture Research Topics

Disease

5Inflammation (Inflammations)
01/2017 - 10/2001
5Pain (Aches)
12/2013 - 10/2001
4Insulin Resistance
01/2017 - 09/2007
4Hyperalgesia
02/2008 - 10/2001
3Hypertension (High Blood Pressure)
03/2013 - 12/2007
2Necrosis
01/2017 - 03/2012
2Septic Shock (Toxic Shock Syndrome)
04/2015 - 02/2008
2Cardiovascular Diseases (Cardiovascular Disease)
01/2013 - 01/2005
2Tachycardia (Tachyarrhythmias)
12/2001 - 05/2000
1Type 2 Diabetes Mellitus (MODY)
01/2017
1Obesity
01/2017
1Edema (Dropsy)
04/2015
1Hyperglycemia
04/2015
1Thrombosis (Thrombus)
04/2015
1Ganglion Cysts (Ganglion)
12/2013
1Epilepsy (Aura)
09/2013
1Central Nervous System Diseases (CNS Diseases)
09/2013
1Seizures (Absence Seizure)
09/2013
1Periodontal Diseases (Periodontal Disease)
06/2009
1Diabetic Retinopathy (Retinopathy, Diabetic)
05/2008
1Peripheral Nerve Injuries
02/2008
1Sepsis (Septicemia)
02/2008
1Neuralgia (Stump Neuralgia)
02/2008
1Diabetes Mellitus
12/2007
1Polyneuropathies (Polyneuropathy)
09/2007
1Stroke (Strokes)
01/2005
1Nervous System Diseases (Neurological Disorders)
01/2005
1Neoplasms (Cancer)
01/2005
1Rheumatoid Arthritis
01/2005
1Hypersensitivity (Allergy)
01/2005
1Shock
01/2005
1Asthma (Bronchial Asthma)
01/2005
1Demyelinating Diseases (Demyelinating Disease)
10/2001
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/2001
1Multiple Sclerosis
10/2001
1Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
11/2000

Drug/Important Bio-Agent (IBA)

11KininsIBA
04/2015 - 10/2001
42- ((3- (1,3- benzodioxol- 5- yl)- 3- (((6- methoxy- 2- naphthyl)sulfonyl)amino)propanoyl)amino)- 3- (4- ((2,6- dimethylpiperidinyl)methyl)phenyl)- N- isopropyl- N- methylpropanamideIBA
01/2017 - 09/2007
4Peptides (Polypeptides)IBA
09/2013 - 01/2005
42,5-dichloro-4-bromophenol (B 2)IBA
01/2013 - 10/2001
3Proteins (Proteins, Gene)FDA Link
01/2017 - 12/2013
3Messenger RNA (mRNA)IBA
04/2015 - 02/2008
3Glucose (Dextrose)FDA LinkGeneric
03/2012 - 09/2007
3Insulin (Novolin)FDA Link
03/2012 - 09/2007
2BradykininIBA
09/2013 - 01/2005
2Angiotensin IIIBA
03/2013 - 04/2010
2AntioxidantsIBA
05/2008 - 12/2007
2fumarate N- ((4- (4,5- dihydro- 1H- imidazol- 2- yl)phenyl)methyl)- 2- (2- (((4- methoxy- 2,6- dimethylphenyl) sulfonyl)methylamino)ethoxy)- N- methylacetamideIBA
02/2008 - 12/2007
2AutacoidsIBA
01/2005 - 10/2001
1Pioglitazone (Actos)FDA Link
01/2017
1LigandsIBA
01/2017
1ChemokinesIBA
01/2017
1Bradykinin B1 ReceptorIBA
01/2017
1PPAR gammaIBA
01/2017
1Evans Blue (Blue, Evans)FDA Link
04/2015
1Coloring Agents (Dyes)IBA
04/2015
1bovine adrenal medulla 8-22IBA
12/2013
1Kainic Acid (Kainate)IBA
09/2013
1palmitoleic acidIBA
03/2012
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
03/2012
1Fatty Acids (Saturated Fatty Acids)IBA
03/2012
1Antihypertensive Agents (Antihypertensives)IBA
04/2010
1RacloprideIBA
04/2010
1Haloperidol (Haldol)FDA LinkGeneric
04/2010
1Dopamine Receptors (Dopamine Receptor)IBA
04/2010
1CalciumIBA
06/2009
1Vitamin DFDA LinkGeneric
06/2009
1EndotoxinsIBA
02/2008
1LF 16-0687IBA
02/2008
1LipopolysaccharidesIBA
02/2008
1R 715IBA
12/2007
1Thioctic Acid (Lipoic Acid)IBA
12/2007
1Superoxides (Superoxide)IBA
09/2007
1peptide BIBA
09/2007
1Therapeutic UsesIBA
01/2005
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2005
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2005
1KallidinIBA
01/2005
1NK 2 (NK-2)IBA
12/2001
1Adrenergic Receptors (Adrenergic Receptor)IBA
12/2001
1R 820IBA
12/2001
1SR 48968 (saredutant)IBA
12/2001
1TachykininsIBA
12/2001
1Atenolol (Tenormin)FDA LinkGeneric
12/2001
1senktideIBA
12/2001
1Streptozocin (Streptozotocin)FDA Link
10/2001
1EicosanoidsIBA
11/2000
1CytokinesIBA
11/2000
1des-Arg(9)- bradykininIBA
05/2000

Therapy/Procedure

2Therapeutics
12/2007 - 09/2007
1Induced Hyperthermia (Thermotherapy)
04/2015
1Ligation
02/2008